On September 3rd 2003, 34 year old mother Lisa Shuttleworth vanished from her Aiken, South Carolina home. Her kids came home to find themselves locked out of the house. In the driveway was her car which had broken down, and a car that she had borrowed until she could get hers fixed. When Lisa's mom arrived at the house and used a key to get in, there was no sign of Lisa. There was a pot of tea undisturbed on the stove, and there was no sign of a struggle. It appeared that Lisa had just stepped out and planned to return, but she never did.

On November 2nd, 1978 24 year old Barbara Annette McClure went out for a night of dancing at the Fandango Disco in Seattle Washington on. That night, she and her dance partner who she had briefly dated got into a minor argument. Reportedly, the man she was dancing with left the club, and a short while later, Barbara also left. People that knew Barbara claimed that they saw her walking near the 16500 block of Bothell Way northwest, about half a mile from the disco, and they claimed they offered her a ride but she refused, and insisted on walking 5 miles to her home. She didn't make it home, and was never seen again. The lines of what happened that night are blurred by inaccuracies and confusion. A neighbor boy who babysat Barbara's 2 year old daughter Jamie, swears that he babysat that night and in the early morning hours, was told by a strange man to go home. Somehow, Jamie wound up in the care of her family that morning and it's not clear how. There is also speculation that the witnesses who las saw Barbara may not be telling the full truth. Finally, there is reason to believe that Barbara's father who she was estranged from was having her followed when she went missing. Days after Barbara vanished, her driver's license was found about ten miles away in a culdesac. The case went cold, and Jamie now an adult, is trying to get to the bottom of what happened. In this episode, she discusses her efforts, and all of the confusion in the case.

On February 6th, 1996, 11 year old Loukthayoth Phiangdae, who went by Luke, vanished from his home in Raymond, Washington. He was apparently upset after being yelled at by his father for roughhousing with his brother, and he headed into his bedroom locking the door behind him. After several minutes, his family went to check on Luke and found his door locked. After forcing their way in, they found out that Luke was gone. It seemed like he had left through his window, and to this date, he has never been found despite extensive searches, and FBI involvement. Although there were possible sightings of Luke, none were confirmed, and it's not clear if he ran away, or was abducted. Over the years, suspicion fell on Luke's father, and some theorize that Luke drowned. In the end, there is not enough clues to look in any direction to figure out what happened to the 11 year old.