In March, 2001 eleven year old Bethany Markowski vanished in Tennessee while on a visit with her father Larry. Larry and Bethany's mom Jonnie had recently split up after a volatile relationship amidst allegations of abuse on Larry's part towards Jonnie. Jonnie had fled her home with few belongings, alongside Bethany hoping that they could get away from Larry. Eventually, Larry caught up with them, and a protection order was put in place. Since Larry had never abused Bethany, he had visitation rights, and Bethany would spend weekends with him. But on just the second visit with her father, Bethany vanished. On Sunday, March 4th, 2001, Larry was supposed to drop off Bethany after their visit. According to Larry, he stopped at the Old Hickory shopping mall in Jackson, TN so that Bethany could go inside and pick up a few things. Larry claims that after not returning for a period of time, he went into the mall to find his daughter, but he never did. Witnesses backed up Larry's story that he was in the mall that day, but none of those witnesses saw Bethany, and she hasn't been seen since. Since she vanished, Larry has reportedly failed polygraph tests, and has stopped cooperating with police. He has never been charged in the case and denies any involvement in his daughter's disappearance.

On September 3rd 2003, 34 year old mother Lisa Shuttleworth vanished from her Aiken, South Carolina home. Her kids came home to find themselves locked out of the house. In the driveway was her car which had broken down, and a car that she had borrowed until she could get hers fixed. When Lisa's mom arrived at the house and used a key to get in, there was no sign of Lisa. There was a pot of tea undisturbed on the stove, and there was no sign of a struggle. It appeared that Lisa had just stepped out and planned to return, but she never did.

On November 2nd, 1978 24 year old Barbara Annette McClure went out for a night of dancing at the Fandango Disco in Seattle Washington on. That night, she and her dance partner who she had briefly dated got into a minor argument. Reportedly, the man she was dancing with left the club, and a short while later, Barbara also left. People that knew Barbara claimed that they saw her walking near the 16500 block of Bothell Way northwest, about half a mile from the disco, and they claimed they offered her a ride but she refused, and insisted on walking 5 miles to her home. She didn't make it home, and was never seen again. The lines of what happened that night are blurred by inaccuracies and confusion. A neighbor boy who babysat Barbara's 2 year old daughter Jamie, swears that he babysat that night and in the early morning hours, was told by a strange man to go home. Somehow, Jamie wound up in the care of her family that morning and it's not clear how. There is also speculation that the witnesses who las saw Barbara may not be telling the full truth. Finally, there is reason to believe that Barbara's father who she was estranged from was having her followed when she went missing. Days after Barbara vanished, her driver's license was found about ten miles away in a culdesac. The case went cold, and Jamie now an adult, is trying to get to the bottom of what happened. In this episode, she discusses her efforts, and all of the confusion in the case.